Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

摘要

Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula:where:at least two of A-E are nitrogen, with the remaining atom(s) carbon;X=NH or NR<7>, such that R<7>=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms);n=0, 1, 2.The remaining substituents are described in detail in the specification.