Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone

摘要

The present invention relates to a process for the in situ preparation of optically pure (S)-3,4-dihydroxybutyric acid derivatives represented by the Formula [2] and more particularly, to a process which enables preparing optically pure (S)-3-hydroxy-gamma-butyrolactone represented by Formula [1] by oxidation of alpha- or beta-(1,4) linked disaccharide or oligosaccharide with an oxidant under basic condition to give acid and cyclization sequentially under acidic condition to give (S)-3-hydroxy-gamma-butyrolactone.