发明名称 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation |
摘要 |
The present invention provides a method for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups. Methods of use of the mass-coded combinatorial library produced by this method for identifying a ligand to a particular biomolecule are also disclosed.
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申请公布号 |
US6714875(B1) |
申请公布日期 |
2004.03.30 |
申请号 |
US19990373018 |
申请日期 |
1999.08.11 |
申请人 |
NEOGENESIS DRUG DISCOVERY, INC. |
发明人 |
NASH HUW M.;BIRNBAUM SETH;WINTNER EDWARD A.;KALGHATGI KRISHNA;SHIPPS GERALD;JINDAL SATISH |
分类号 |
B01J19/00;C07B61/00;C40B40/06;C40B70/00;(IPC1-7):G01N24/00;G01N33/53 |
主分类号 |
B01J19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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