РАСЩЕПЛЯЕМЫЕ ПЕПТИДАЗОЙ ЦЕЛЕВЫЕ ПРОТИВООПУХОЛЕВЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВА И ИХ ТЕРАПЕВТИЧЕСКОЕ ИСПОЛЬЗОВАНИЕ

摘要

This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.