Intermediates and methods for synthesizing 2-chloro-9- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine

摘要

2-chloro-9-(2-deoxy-2-fluoro-â-D-arabinofuranosyl)-9H- purin-9-amine is synthesised by reacting a 2-chloro-6- substituted purine with a protected and activated 2-deoxy-2- fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-â-D- arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.