Process for preparing inhibitors of nucleoside metabolism

摘要

A process of preparing a compound of the formula (I) where, - B is chosen from OH, NH2, NHR, H or halogen or SCH3, - D is chosen from OH, NH2, NHR, H, halogen or SCH3; - R is an optionally substituted alkyl, aralkyl or aryl group; - Z is selected from OH, hydrogen, halogen, OH, SQ or OQ; - Q is an optionally substituted alkyl, aralkyl or aryl group. Also disclosed is an intermediate compound of formula (XX) where: - R9 is a hydrogen atom, an alkoxycarbonyl or aralkyloxycarbonyl group, - Z' is a hydrogen or halogen atom, a hydroxy group, a group of formula SQ or OQ, or atrialkylsilyloxy, alkyldiarylsilyloxy or optionally substituted triarylmethoxy group; - Q is an optionally substituted alkyl, aralkyl or aryl group; - R6 is an N protecting group, - B' and D' are independently selected from H, OR7 and N(R8)2, and R7 and R8 and O-and N-protecting groups respectively. Also disclosed is an intermediate compound of formula (A) where Y is an unsubstituted or substituted alkyl or arylalkyl group having 1 to 8 carbon atoms.