| 摘要 |
PURPOSE: Pharmaceutical compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia are provided, thereby effectively treating and preventing tumors and tumor-related disorders and cachexia by certain cyclooxygenase-2 inhibitors. CONSTITUTION: The pharmaceutical compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia comprises a compound of formula (I),(II) and pharmaceutically acceptable salts thereof, wherein R represents a hydrogen atom, a halogen atom or a lower alkyl group; R1 represents a lower alkyl group, an amino group or a group of formula -NHRa in which Ra represents a group which may be eliminated in vivo; R2 represents a phenyl group or a phenyl group which is substituted by at least one of substituents alpha or substituents beta , defined below; R3 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkyl group which is substituted by at least one of substituents alpha ; R4 represents a hydrogen atom, a lower alkyl group, a lower alkyl group which is substituted by at least one of substituents alpha, a cycloalkyl group, an aryl group.
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