| 摘要 |
Disclosed herein is a method of monitoring a freeze- drying process in an apparatus (1) holding one or more samples (9) of a material to be freeze dried, wherein the method comprises the steps of directing input radiation onto the sample (9), the input radiation forming output radiation by interaction with the sample (9); collecting at least part of the output radiation and leading the thus collected radiation to a radiation analyzer (11); and analyzing the collected radiation spectroscopically in the radiation analyzer (11) to obtain a measurement value of one or more freeze-drying parameters of the sample (9), such as the temperature of the sample (9) and/or the content of a solvent in the sample (9) and/or the structure of the sample (9). This method of monitoring is suitable for freeze-drying or lyophilisation process for stabilization of degradable material such as micro- organisms, food items, biological products or pharmaceuticals and is also suitable for aseptic treatment of a material.
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