发明名称 |
METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITHIN A CELL |
摘要 |
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that . In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. |
申请公布号 |
WO2004024872(A2) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003US28732 |
申请日期 |
2003.09.10 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;QIN, XIAO-FENG;BALTIMORE, DAVID |
发明人 |
QIN, XIAO-FENG;BALTIMORE, DAVID |
分类号 |
A61K38/00;A61K48/00;C12N15/11;C12N15/113;C12N15/867 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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