发明名称 |
PMEA AND PMPA CYCLIC PRODUCING SYNTHESIS |
摘要 |
<p>The method of preparing compounds of Formula I is described: Formula Iwherein:M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, and (R)-9-(2-phosphonylmethoxypropyl)adenine; wherein V is phenyl, optionally substituted with 1-2 substituents selected from a group consisting of fluoro, chloro, and bromo; comprising:coupling a chiral 1-phenylpropane-1,3-diol, wherein the phenyl may be optionally substituted, with MPOCl2 or an N-6 substituted analogue thereof.Additionally, methods and salt forms are described that enable isolation and purification of the desired isomer.</p> |
申请公布号 |
WO03095665(A3) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003US14822 |
申请日期 |
2003.05.12 |
申请人 |
METABASIS THERAPEUTICS, INC.;KOPCHO, JOSEPH J.;REDDY, K. RAJA;MATELICH, MICHAEL C.;UGARKAR, BHEEMARAO G. |
发明人 |
KOPCHO, JOSEPH J.;REDDY, K. RAJA;MATELICH, MICHAEL C.;UGARKAR, BHEEMARAO G. |
分类号 |
A61K31/66;A61P31/12;A61P31/18;A61P35/00;C07F9/6571;C07F9/6574;(IPC1-7):C07F9/657 |
主分类号 |
A61K31/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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