| 摘要 |
The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R<1 >and R<2 >taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl; R<3 >is hydrogen or halo; R<4 >is hydrogen or C1-6alkyl; R<5 >is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula -Alk-R<6>-, Alk-X-R<7>, -Alk-Y-C(=O)-R<9>, or -Alk-Y-C(=O)-NR<11>R<12 >wherein each Alk is C1-12alkanediyl; and R<6 >is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R<7 >is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR<8>; said R<8 >being hydrogen or C1-6alkyl; R<9 >is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR<10 >or a direct bond; said R<10 >being hydrogen, or C1-6alkyl; R<11 >and R<12 >each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R<11 >and R<12 >combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
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