发明名称 |
COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE |
摘要 |
We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained from one clade or from two or more different clades, and the antigens selected and/or the manner in which the vectors are formulated (e.g., mixed) can be manipulated to generate a protective immune response against a variety of clades (e.g., the clades to which a patient is most likely to be exposed; with the proportions of the components of the vaccine tailored to the extent of the patient's risk to a particular clade or clades). |
申请公布号 |
WO03076591(A3) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003US07177 |
申请日期 |
2003.03.10 |
申请人 |
EMORY UNIVERSITY;UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES;ROBINSON, HARRIET, L.;SMITH, JAMES;HUA, JIAN;MOSS, BERNARD |
发明人 |
ROBINSON, HARRIET, L.;SMITH, JAMES;HUA, JIAN;MOSS, BERNARD |
分类号 |
C12N15/09;A61K35/76;A61K39/21;A61K48/00;A61P31/18;C07K14/16;C12N7/04;C12N15/70;C12N15/85;C12N15/863 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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