发明名称 |
PREPARATION AND USE OF MIXED MODE SOLID SUBSTRATES FOR CHROMATOGRAPHY ADSORBENTS AND BIOCHIP ARRAYS |
摘要 |
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption. |
申请公布号 |
WO2004024318(A1) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003US28688 |
申请日期 |
2003.09.12 |
申请人 |
CIPHERGEN BIOSYSTEMS, INC.;BOSCHETTI, EGISTO;GIROT, PIERRE;UM, PIL-JE |
发明人 |
BOSCHETTI, EGISTO;GIROT, PIERRE;UM, PIL-JE |
分类号 |
G01N27/62;B01D15/18;B01J20/281;B01J20/286;B01J20/32;B01J20/34;C07K1/22;C40B40/10;G01N1/04;G01N30/88;G01N33/543;G01N35/00 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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