发明名称 |
A NOVEL MECHANISM FOR HIV-1 ENTRY INTO HOST CELLS AND PEPTIDES INHIBITING THIS MECHANISM |
摘要 |
This invention relates to the finding that TAT interacts with gp120 at the cell surface and enhances HIV-1 entry into host cells. This invention also discloses modulators of this interaction, particularly peptides that mimic the region of gp120 involved in this interaction. These peptides interfere with TAT-mediated enhancement of infection regardless of virus strain, and are therefore suitable for the development in general of broad-range drugs against AIDS and other infectious diseases induced by HIV-1 related pathogens, and specifically for a class of chemicals active in the reduction or abrogation of virus and infectivity spreading. |
申请公布号 |
WO2004024173(A2) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003EP10162 |
申请日期 |
2003.09.12 |
申请人 |
CREABILIS THERAPEUTICS S.R.L.;BUSSOLINO, FEDERICO;MARCHIO, SERENA |
发明人 |
BUSSOLINO, FEDERICO;MARCHIO, SERENA |
分类号 |
A61K38/00;A61K38/16;A61P31/18;C07K7/06;C07K7/08;C07K14/16;G01N33/569;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|