发明名称 |
Processes for preparing clarithromycin polymorphs and novel polymorph IV |
摘要 |
The present invention relates to processes for converting clarithromycin Form 0 to clarithromycin Form II, which include slurrying clarithromycin the Form 0 in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form 0 to clarithromycin Form II by slurrying. The present invention further relates to the novel clarithromycin polymorph Form IV, a process for its preparation, pharmaceutical compositions comprising the compound, and methods of using the compound as a therapeutic agent.
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申请公布号 |
US2004058879(A1) |
申请公布日期 |
2004.03.25 |
申请号 |
US20030459124 |
申请日期 |
2003.06.10 |
申请人 |
AVRUTOV ILYA;LIFSHITZ IGOR;BOROCHOVITZ RONEN;MASARWA BASEM;SCHWARTZ EDI |
发明人 |
AVRUTOV ILYA;LIFSHITZ IGOR;BOROCHOVITZ RONEN;MASARWA BASEM;SCHWARTZ EDI |
分类号 |
A61K9/06;A61K9/10;A61K9/14;A61K31/7048;A61P31/04;C07H17/08;(IPC1-7):A61K31/704 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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