摘要 |
This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising alpha-D-Gal(1->3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of alpha-D-galactopyranosyl-(1->3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R<3 >is methoxy or methyl; R<1 >is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R<2 >is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.
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