Process for the industrial synthesis of tetraesters of 5-[BIS(CARBOXYMETHYL)AMINO]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

摘要

Process for the industrial synthesis of compounds of formula (I): wherein R and R' which are the same or different, each represent linear or branched (C1-C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.