SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD

摘要

Formula, wherein Z<1> is (CH2)q or C=O; Z<2> is (CH2)p or C=O; D is -CH= or C=O or (CH2)m where m is 0, 1, 2 or 3; n = 0, 1 or 2; p = 1 or 2; q = 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x<1>, where x<1> is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x<2>-O-(CH2)x<3 >- where x<2> is 0 to 5 and x<3> is 0 to 5, provided that at least one of x<2> and x<3> is other than 0; B is a bond or is (CH2)x<4> where x<4> is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C. R<1> is H or alkyl; R<2> is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R<2a>, R<2b> and R<2c> may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R<3>, E, Z and Y are as defined herein.