4-(3,5-DICYANOPHENOXY) PYRAZOLE DERIVATIVES FOR USE AS REVERSE TRANSCRIPTASE MODULATORS IN THE TREATMENT OF I.A. HIV

摘要

This invention relates to the pyrazole derivatives of formula (I) and pharmaceutically acceptable salt, solvate or derivatives thereof, to their u se in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. The compounds of th e invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors, thereof. Reverse transcriptase is implicated in the infectious lifecycle of Human Immunodeficiency Virus (HIV). Compounds which interfere with the function of this enzyme have shown utility in the treatme nt of conditions caused by HIV and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).