PIPERIDINE QUINOLYL PROPYL DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES AND COMPOSITIONS CONTAINING SAME

摘要

The invention concerns piperidine quinolyl derivatives of general formula (I), wherein: R1 is hydrogen or fluorine; R2 is carboxy, carboxymethyl or hydroxymethyl; R3 is alkyl substituted either by a phenylthio optionally substituted by halogen, hydroxy, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxy, alkoxycarbonyl, cyano or amino, or by cycloalkylthio (3 to 7 members) optionally substituted by halogen or trifluoromethyl, or heteroalkylthio (5 to 6 members and 1 to 4 heteroatoms, selected among N, O and S), optionally substituted by halogen, hydroxy, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxy, alkyloxycarbonyl, cyano or amino or R3 is propargyl substituted by phenyl, or heteroaryl such as defined above; R4 is alkyl, alkenyl-CH2- or alkynyl-CH2-, cycloalkyl or cycloalkyl alkyl, in their various isomeric separated or mixed forms, as well as their salts. The method also concerns a method for preparing said derivatives and compositions containing them. Said novel derivatives are potent antibacterial agents.