Immunogenicity-enhancing carriers and compositions thereof and methods of using the same

摘要

The present invention is directed to compositions comprising a substantially non-antigenic carrier associated with an antigen and the use of such compositions to enhance the immunogenicity of the associated antigen. In addition, the compositions of the invention may be used to generate an immune response directed predominantly to an antigen associated with a carrier. Specific carriers of the invention include homopolymers and copolymers of polyamino acids. Compositions of the invention are used according to the invention to elicit or enhance an immune response directed against an antigen and may be used for the prevention and treatment of infection and disease, for example. Additionally, compositions of the invention are useful for generating an antibodies specific for an antigen and, accordingly, may be used to generate antigen-specific antibodies suitable for the diagnosis or treatment of infection and disease.