发明名称 |
Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants |
摘要 |
Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or Abeta fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or Abeta fibrillogenesis. Related extraction methods are disclosed.
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申请公布号 |
US2004057964(A1) |
申请公布日期 |
2004.03.25 |
申请号 |
US20030624435 |
申请日期 |
2003.07.21 |
申请人 |
CASTILLO GERARDO;CHOI PAULA Y.;NGUYEN BETH;SNOW ALAN D. |
发明人 |
CASTILLO GERARDO;CHOI PAULA Y.;NGUYEN BETH;SNOW ALAN D. |
分类号 |
A61K31/353;A61K31/215;A61K31/216;A61K31/35;A61K36/00;A61K36/18;A61K36/74;A61P3/10;A61P25/00;A61P25/28;A61P31/00;A61P35/00;A61P43/00;C12N;C12N9/99;(IPC1-7):A61K35/80;A61K35/78 |
主分类号 |
A61K31/353 |
代理机构 |
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代理人 |
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地址 |
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