DNA MOLECULE WITH INSULATING ACTIVITY AGAINST CHROMOSOMAL POSITION EFFECTS IN GENE TRANSFER PROCESSES IN ANIMAL CELLS

摘要

The invention relates to a DNA molecule or a fragment of said DNA molecule obtained from the LCR (Locus Control Region) sequence of the mouse tyrosinase gene. Said sequence has insulating activity against chromosomal position effects in gene transfer processes in animal cells. The DNA molecule can be used to introduce transgenes and to reduce the variability of the transgene expression in animal cells. <IMAGE>