发明名称 |
Membrane-based assays |
摘要 |
Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by an aqueous film, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Arrays may be engineered to display natural membrane materials in a native fluid bilayer configuration, permitting high-throughput discovery of drugs that target and affect membrane components. The membrane-based assays detect binding events by monitoring binding-induced changes in one or more physical properties of fluid bilayers.
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申请公布号 |
US2004053337(A1) |
申请公布日期 |
2004.03.18 |
申请号 |
US20030661790 |
申请日期 |
2003.09.11 |
申请人 |
SYNAMEM CORPORATION, A CALIFORNIA CORPORATION |
发明人 |
YAMAZAKI MIKI;SCHAFER ROBERT J.;ULMAN MORRISON;GROVES JOHN T. |
分类号 |
G01N24/10;C12Q1/18;C40B30/04;G01N13/10;G01N13/16;G01N13/24;G01N21/78;G01N27/02;G01N27/447;G01N33/15;G01N33/483;G01N33/50;G01N33/543;G01N33/566;G01N33/68;G01N37/00;(IPC1-7):G01N33/53 |
主分类号 |
G01N24/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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