LIQUID STABLE COMPOSITION OF OXAZAPHOSPHORINE WITH MESNA

摘要

A low toxicity, stable oxazaphosphorine containing compositions with mesna f or parenteral administration has been described. The process essentially requir es addition of an oxazaphosphorine antineoplastic to the aqueous solution of an etherified b-cyclodextrin followed by addition of mesna as such or as an aqueous solution containing optionally, an etherified b-cyclodextrin. Preferably, the oxazaphosphorine antineoplastic is Ifosfamide and the etherified b-cyclodextrin is 2-hydroxypropyl-b-cyclodextrin.