| 摘要 |
<p>This invention relates aryl substituted thiazolidinones of Formula I: (I) or a pharmaceutically acceptable salt, or solvate thereof, wherein n is an integer from 1 to 2; R1 is selected from the group consisting of: (I) where Y is alkylene and R3 and R4 are the same or different and are selected from hydrogen, alkyl, or aryl, or R3 and R4 together form an alkylene chain having 4 to 5 carbon atoms optionally interrupted by a nitrogen or oxygen; (ii) pyridylalkyl; and (iii) piperidin-4-yl, optionally substituted phenyl; 2,2-diphenylethenyl; furanyl; carbozolyl. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute chronic pain, as antimanic depressants, as local as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.</p> |
