摘要 |
Compounds of formula (I) wherein: X is N; R<SUB>1 </SUB>is C<SUB>1</SUB>-C<SUB>6 </SUB>linear or branched alkyl or C<SUB>1</SUB>-C<SUB>6 </SUB>linear or branched alkenyl; R<SUB>2 </SUB>is hydrogen, C<SUB>1</SUB>-C<SUB>6 </SUB>linear or branched alkyl or C<SUB>1</SUB>-C<SUB>6 </SUB>linear or branched alkenyl, C<SUB>6</SUB>-C<SUB>14 </SUB>aryl or C<SUB>6</SUB>-C<SUB>14 </SUB>aryl(C<SUB>1</SUB>-C<SUB>6</SUB>) linear or branched alkyl or C<SUB>6</SUB>-C<SUB>14 </SUB>aryl(C<SUB>1</SUB>-C<SUB>6</SUB>) linear or branched alkenyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting of halogen, hydroxy, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy linear or branched or C<SUB>1</SUB>14 C<SUB>6 </SUB>alkenyloxy linear or branched, amino, optionally mono- or disubstituted with C<SUB>1</SUB>-C<SUB>6 </SUB>linear or branched alkyl; R<SUB>3 </SUB>is NH<SUB>2</SUB>, NHR<SUB>4</SUB>; R<SUB>4 </SUB>is C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl or C<SUB>1</SUB>-C<SUB>6 </SUB>hydroxyalkyl, C<SUB>1</SUB>-C<SUB>3 </SUB>alkoxyalkyl, amino(C<SUB>1</SUB>-C<SUB>6</SUB>)alkyl, where the amino group is optionally substituted with one or two C<SUB>1</SUB>-C<SUB>3 </SUB>linear or branched alkyl groups, or with one or two C<SUB>2</SUB>-C<SUB>3 </SUB>alkenyl groups C<SUB>6</SUB>-C<SUB>14 </SUB>aryl or C<SUB>6</SUB>-C<SUB>14 </SUB>aryl(C<SUB>1</SUB>-C<SUB>6</SUB>)alkyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting by halogen, hydroxy, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy linear or branched or C<SUB>1</SUB>-C<SUB>6 </SUB>alkenyloxy linear or branched, amino, mono- or di-substituted with C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl linear or branched or C<SUB>1</SUB>-C<SUB>6 </SUB>alkenyl linear or branched; and their pharmaceutically acceptable salts. These compounds are antagonists of the adenosine A<SUB>2a </SUB>receptor and useful as medicaments, in particular for the treatment of Parkinson's disease. |