发明名称 |
Process for manufacture of a 4-bromo-2-oxyimino butyric acid and its derivatives |
摘要 |
A process for producing 4-bromo-2-oxyimino butyric acid, predominantly as the (Z)-isomer of formula (I), wherein R is hydrogen; a linear or branched C1-4 alkyl group; a linear or branched C1-4 alkyl group substituted by a carboxylic acid or an aryl group; a substituted or unsubstituted cyclic alkyl group of 3-6 carbon atoms or a substituted or unsubstituted aryl group. The product is produced by reacting bromine with a 2-(oxyimino)-3-oxo butyric acid derivative of formula (II) wherein R is as defined above and R<1 >is a tert-butyl group in presence of an organic solvent and in presence of a C1-4 alcohol and acetyl bromide at a temperature ranging from about -15° C. to about +15° C. Bromine is used in a proportion of about 0.90 to about 1.35 moles per mole of compound (II), preferably 0.90 to 1.10 moles. The acetyl bromide is used in molar proportions of 0.9 to 2 moles per mole of compound (II), preferably 0.9 to 1.5 moles.
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申请公布号 |
US2004054224(A1) |
申请公布日期 |
2004.03.18 |
申请号 |
US20030465926 |
申请日期 |
2003.06.26 |
申请人 |
KANSAL VINOD KUMAR;RANE DNYANDEO RAGHO;DESHMUKH SANJAY;SINGH SANTOSH KUMAR;RICHARIA SANTOSH;ABRAHAM SUSAN AJAY |
发明人 |
KANSAL VINOD KUMAR;RANE DNYANDEO RAGHO;DESHMUKH SANJAY;SINGH SANTOSH KUMAR;RICHARIA SANTOSH;ABRAHAM SUSAN AJAY |
分类号 |
A61B17/00;C07B39/00;C07C249/12;C07C251/36;C07C251/60;(IPC1-7):C07C251/36 |
主分类号 |
A61B17/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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