发明名称 |
METHODS AND MEANS OF HISTONE METHYLATION |
摘要 |
This invention relates to the methylation of histones, in particular to a previously uncharacterised group of histone H3 methylases which comprise a SET domain and which methylate either lysine 4 within the amino tail of histone H3 or within the histone H3 core. Methylation by these methylases, in particular trimethylation, is shown to be important for transcriptional activity. |
申请公布号 |
WO02090578(A3) |
申请公布日期 |
2004.03.18 |
申请号 |
WO2002GB02050 |
申请日期 |
2002.05.02 |
申请人 |
CHROMA THERAPEUTICS LIMITED;KOUZARIDES, TONY;SANTOS-ROSA, HELENA |
发明人 |
KOUZARIDES, TONY;SANTOS-ROSA, HELENA |
分类号 |
A61K38/00;C12N9/10;C12Q1/48;G01N33/573 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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