| 发明名称 |
Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
| 摘要 |
Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
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| 申请公布号 |
US2004054212(A1) |
申请公布日期 |
2004.03.18 |
| 申请号 |
US20030660439 |
申请日期 |
2003.09.10 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
VENIT JOHN J.;DALL MANDAR V.;DALL MANISHA M.;HUANG YANDE;DAHLHEIM CHARLES E.;TEJWANI RAVINDRA W. |
| 分类号 |
A61P35/00;C07C211/14;C07C215/10;C07C215/12;C07C229/08;C07C229/26;C07C279/14;C07D233/54;C07D233/61;C07F9/12;(IPC1-7):C07F9/02 |
主分类号 |
A61P35/00 |
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