METHOD FOR DETECTING EXPRESSION OF PRION PROTEIN GENE, KIT FOR DETECTION, DETECTING REAGENT, INHIBITOR OF EXPRESSION OF PRION PROTEIN GENE AND PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR PRION DISEASE

摘要

PROBLEM TO BE SOLVED: To provide a method for detecting expression of a prion protein gene by which the prion protein can precisely be detected, a kit for detection, an apparatus for detection, an inhibitor of the expression of the prion protein gene useful for treating a prion disease, a prophylactic and/or a therapeutic agent for the prion disease, a method for treatment and a method for inhibition.

SOLUTION: The method for detecting the expression of the prion protein gene comprises a step of detecting an acidic isoform and a basic isoform of a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a tissue derived from a human or an animal. The inhibitor of the expression of the prion protein increases the basic isoform of the GAPDH and/or reduces the acidic isoform thereof. The prophylactic and/or therapeutic agent comprises the inhibitor.

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