| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for detecting protein association by changes in a diffusion constant. SOLUTION: A target protein is dispersed in a protein-containing liquid, and matter to be tested, such as another protein, is added to the protein-containing liquid. A pair of pulse laser beams 14 of the same wavelength for excitation are made incident onto a particle mixed system 13, generated by the addition in such a way as to intersect each other in the mixed system to generate a transient diffraction grating. A laser beam 15 of another wavelength for a probe is made incident onto the transient diffraction grating at another angle. By measuring the intensity of transient diffracted waves of the laser beam, changes in the diffusion constant are measured. COPYRIGHT: (C)2004,JPO
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