Joint utilization of the insulin gene and the glucokinase gene in the development of therapeutic approaches for diabetes mellitus

摘要

This invention relates to a double transgenic animal that simultaneously expresses the gene or the cDNA (complementary DNA) of insulin and the gene or the cDNA (complementary DNA) of glucokinase directed by a promoter or fusion of promoters which permit insulin and glucokinase to be expressed in muscle and its use in the development of therapeutic approximations for diabetes mellitus. This invention also relates to a vector or vectors of expression which permits the expression of said chimeric genes jointly in muscle cells. Said vectors can be a plasmid, a viral vector or a non-viral vector.