| 摘要 |
This invention relates to compounds which have the ability to potentiate the physiological activity of insulin, and in particular to small peptide compounds. The compounds are useful in the treatment of conditions related to insulin resistance, such as non-insulin dependent diabetes mellitus (NIDDM) and obesity. The invention provides a peptide or peptidomimetic compound which has the ability to potentiate one or more of the physiological activities of insulin, in which the peptide comprises the sequence: W-X-Y-Z where W is a basic amino acid, such as lysine, arginine, homolysine, homoarginine or ornithine; X is a neutral aliphatic amino acid, in either the L- or the D-form, such as glycine, leucine, alanine, beta-alanine or isoleucine, homoleucine, norleucine, homonorleucine, cyclohexylalanine, or homocyclohexylalanine; Y is an aromatic amino acid, such as phenylalanine or tyrosine; and Z is an amino acid or amino acid analogue which has a side chain having pi or delocalised electrons, with the proviso that the peptide is not Arg-Gly-Phe-Phe, Arg-Gly-Ser-Arg-Leu-Phe-Phe-Asn-Tyr-Ala-Leu-Val, Arg-Leu-Phe-Asu-Asn-Ala, or Leu-Ser-Arg-Leu-Phe-Asu-Asn-Ala. Compositions and methods of treatment are also within the scope of the invention.
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