A METHOD OF MODULATING ENDOTHELIAL CELL ACTIVITY

摘要

The present invention relates generally to a method of modulating endothelia l cell activity and to agents useful for same. More particularly, the present invention relates to a method of modulating intercellular vascular endotheli al permeability by modulating an intracellular protein kinase C-dependent signalling mechanism. The method for the present invention is useful, inter alia, in the treatment and/or prophylaxis of a condition characterised by aberrant, unwanted or otherwise inappropriate endothelial cell activity, in particular, conditions characterised by a loss of vascular integrity.