Salts of substituted 1,2-dihydro-s-triazines

摘要

The invention comprises salts of triazines of formula with 4,41-methylene bis(3-hydroxy-2-napthoic acid); where X is hydrogen, halogen, methyl or trifluoromethyl, each of Y and Z is hydrogen, halogen, lower (i.e. 1-4 C) alkyl, lower alkoxy, lower alkylthio, trifluoromethyl or benzyloxy, at least one of X, Y and Z being hydrogen; R1 is lower alkyl and R2 is hydrogen or methyl; the salts are prepared by reaction of the components or salts thereof in a solvent. Triazines I may be prepared by reaction of the X,Y,Z-aniline with dicyandiamide and a compound R1R2.CO in the presence of a strong acid: if the compound R1R2.CO is reacted in a second step a biguanide of formula (e.g. p-chlorophenylbiguanide hydrochloride) is first obtained. Pharmaceutical compositions containing the above triazine salts are mentioned for parenteral administration (as suspensions) against bacteria and malaria. Reference has been directed by the Comptroller to Specification 709,906.