The invention provides certain macrocyclic triaza compounds which down-regulate CD4 expression for use in the treatment of autoimmune diseases and inflammatory diseases or conditions. In a specific embodiment, the invention provides certain naphthalene substituted triaza macrocycles which exhibit high activity for down regulation of CD4 expression. In particular, triaza macrocycles having dansyl groups are provided for use in pharmaceutical compositions.
申请公布号
WO02080856(A3)
申请公布日期
2004.03.18
申请号
WO2002US11223
申请日期
2002.04.08
申请人
UNIVERSITY AND COMMUNITY COLLEGE SYSTEM OF NEVADA;BELL, THOMAS, W.;SCHOLS, DOMINIQUE;DEY, KAKA;VERMEIRE, KURT
发明人
BELL, THOMAS, W.;SCHOLS, DOMINIQUE;DEY, KAKA;VERMEIRE, KURT