发明名称 |
Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester |
摘要 |
A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.
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申请公布号 |
US2004054217(A1) |
申请公布日期 |
2004.03.18 |
申请号 |
US20030451814 |
申请日期 |
2003.06.26 |
申请人 |
KONDO NORIHISA;MIMURA HIDEYUKI;NUKUI KAZUNORI;KAWADA KOSUKE;ARAI SHOJI |
发明人 |
KONDO NORIHISA;MIMURA HIDEYUKI;NUKUI KAZUNORI;KAWADA KOSUKE;ARAI SHOJI |
分类号 |
C07C67/307;C07C67/54;C07C67/58;(IPC1-7):C07C69/66 |
主分类号 |
C07C67/307 |
代理机构 |
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