| 摘要 |
A medium or ink solution containing nucleic acid is provided for depositing onto a solid support in the manufacture of biological arrays. The medium has a composition that comprises: about 30% to about 80% by volume of an organic solution comprising dimethylsulfoxide (DMSO), ethylene glycol (EG), formamide, or a combination thereof; a buffer with a pH value of about 3.5-9.5; water; and nucleic acid, wherein the nucleic acid denatures to provide for more favorable hybridization. The buffer can be made from a solution that may contain acetate, citrate, citrate-phosphate, maleate, or succinate. The medium permits long-term storage of nucleic acids in solution without excessive degradation, which is a phenomenon associated with many conventional ink solutions.
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