发明名称 |
Fusion proteins for targeted delivery of antimicrobial peptides |
摘要 |
Microbial infection may be treated by administration of a fusion protein comprising one or more recognition sequences and at least one antimicrobial peptide. In preferred embodiments, a linker peptide connects the recognition sequence and one or more antimicrobial peptides. The recognition sequence may be an immunoglobulin molecule, or fragment thereof, that specifically binds to a target antigen present on a pathogen. The recognition sequence may also be a non-immunological polypeptide, providing that the polypeptide binds specifically to a particular ligand. In presently preferred embodiments the recognition sequence is monoclonal antibody that binds specifically to S. mutans and the antimicrobial peptides are derivatives of histatin.
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申请公布号 |
US2004052814(A1) |
申请公布日期 |
2004.03.18 |
申请号 |
US20010910358 |
申请日期 |
2001.07.19 |
申请人 |
SHI WENYUAN;MORRISON SHERIE L.;TRINH KHAM;WIMS LETITIA;CHEN LI;ANDERSON MAXWELL H. |
发明人 |
SHI WENYUAN;MORRISON SHERIE L.;TRINH KHAM;WIMS LETITIA;CHEN LI;ANDERSON MAXWELL H. |
分类号 |
A61K47/48;C07K16/12;C12N15/82;(IPC1-7):A61K39/02;A61K39/002;C07K14/44;C07K14/195;C07K14/39;C07K14/375 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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