| 摘要 |
The present invention relates to gene silencing, and in particular to compositions of hairpin siRNAs. The present invention also relates to methods of synthesizing hairpin siRNAs and double-stranded siRNAs in vitro and in vivo, and to methods of using such siRNAs to inhibit gene expression. In some embodiments, hairpin siRNAs possess strand selectivity. In other embodiments, more than one hairpin siRNAs is present in a single RNA structure/molecule.
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