发明名称 |
Novel process for preparing phenyl amide of 5-(4-fluorophenyl)-1-[2-((2R, 4R)-4-hydroxy-6-oxotetrahydropyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid |
摘要 |
<p>An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.</p> |
申请公布号 |
CZ20031893(A3) |
申请公布日期 |
2004.03.17 |
申请号 |
CZ20030001893 |
申请日期 |
2001.12.27 |
申请人 |
WARNER-LAMBERT COMPANY LLC |
发明人 |
BUTLER DONALD EUGENE;DEJONG RANDALL LEE;NELSON JADE DOUGLAS;PAMMENT MICHAEL GERARD;STUK TIMOTHY LEE |
分类号 |
A61K31/4025;C07B61/00;C07D207/34;C07D295/18;C07D295/185;C07D405/06;C07D413/04;(IPC1-7):C07D405/06 |
主分类号 |
A61K31/4025 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|