发明名称 Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salt
摘要 The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following formula:wherein R<1>, R<2>, R<3 >and R<4 >are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitrile group, a C1-6 alkyl group, a C1-6 alkoxy group etc.; R<5 >represents a hydrogen atom, a halogen atom etc.; the partial structure:is a group represented by the formula >C(R<6>)-CH2- (wherein R<6 >is a hydrogen atom or a halogen atom) or >C=CH-; X- represents a halide ion or organic sulfonic acid ion; and m is 0 or an integer from 1 to 5.
申请公布号 US6706741(B2) 申请公布日期 2004.03.16
申请号 US20020221963 申请日期 2002.09.18
申请人 EISAI CO., LTD. 发明人 IIMURA YOICHI;KOSASA TAKASHI
分类号 A61K31/4425;A61P25/22;A61P43/00;C07D213/46;C07D213/50;(IPC1-7):A61K31/44;C07D211/70;C07D211/82 主分类号 A61K31/4425
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