| 发明名称 |
Compositions and methods comprising immunogenic muteins of interleukin-6 |
| 摘要 |
Cytokines, including muteins thereof, which are biologically inactive in humans but remain immunogenic, are used in pharmaceutical compositions to promote a neutralizing immune response against native cytokines when administered to a subject in need thereof to treat homeostatic disorders and disorders associated with an overproduction of cytokines.
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| 申请公布号 |
US6706261(B1) |
申请公布日期 |
2004.03.16 |
| 申请号 |
US20000559950 |
申请日期 |
2000.04.27 |
| 申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
CILIBERTO GENNARO;SAVINO ROCCO;CORTESE RICCARDO |
| 分类号 |
C12N15/00;A61K38/19;A61K39/00;A61P37/04;A61P43/00;C12N15/01;(IPC1-7):C07K14/54;A61K38/20;C12P21/02 |
主分类号 |
C12N15/00 |
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