发明名称 |
Method of treating disease with radioisotopes conjugated to bioactive substances |
摘要 |
A composition of matter comprises a pathogen-targeting organic moiety which is conjugated to a radioisotope which has a half-life of less than 100 days. The composition can be synthesized by bringing together a radioisotope having a half life of less than 100 days with a greater than stoichiometric amount of a complexing agent so as to form a first mixture containing a reaction product between the radioisotope and the complexing agent; removing the excess complexing agent from the mixture; and bringing together the first reaction product and an antibody substance so as to form a second mixture containing a reaction product between the first reaction product and the antibody substance. The composition is useful for treating infectious diseases caused by pathogens.
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申请公布号 |
US6706252(B1) |
申请公布日期 |
2004.03.16 |
申请号 |
US19980183454 |
申请日期 |
1998.10.30 |
申请人 |
RX/IBR CORPORATION |
发明人 |
ERICSSON ARTHUR DALE;HRNA DANIEL;MALONEY THOMAS J. |
分类号 |
A61K51/12;(IPC1-7):A61K51/00;A61M36/14 |
主分类号 |
A61K51/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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