Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine

摘要

A process for producing compounds of the formula:is disclosed. The compound of formula 1.0 is produced by:(1) separating the atropisomers ofto obtain the atropisomers(2) heating the atropisomer of formula 2.0B at a suitable temperature in a suitable solvent to obtain a mixture of atropisomers of formulas 2.0A and 2.0B; (3) separating the atropisomers of formulas 2.0A and 2.0B of step (2); and (4) reducing the atropisomer of formula 2.0A to obtain a compound of formula 1.0. Preferably, R<1 >is Br, R<2 >is Cl and R<3 >is Br.Also disclosed is the (+)-atropisomer of formula 2.0 wherein R<1 >is Br, R<2 >is Cl and R<3 >is Br.