| 摘要 |
PROBLEM TO BE SOLVED: To provide a sustained-release composition capable of obtaining the sustained-release effect for a long period by an injection of fine particles in an amount not causing pain subcutaneously or intramuscularly. SOLUTION: This sustained-release composition is obtained by filling pores presenting in porous hydroxyappatite fine particles with a physiologically active medicine, human serum protein and mucopolysaccharide, and occluding by adding a divalent metal ion. Also, the composition is obtained by filling the pores presenting in the porous hydroxyappatite fine particles with the physiologically active medicine, the human serum protein and a water soluble calcium salt one by one or at once time and then occluding the outer layer of the fine particles by adding sodium carbonate, sodium hydrogen carbonate or an aqueous solution of carbonate ion. COPYRIGHT: (C)2004,JPO
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