发明名称 |
Modulation of matrix metalloproteinase (MMP) activity with aldosterone blocker(s) |
摘要 |
The present invention is directed to a method for preventing an increase in matrix metalloproteinase (MMP) activity or reducing MMP activity in a subject in need thereof by administering to the subject a therapeutically effective amount of a selective aldosterone blocker. More particularly, the present invention is directed to attenuating or preventing an increase in MMP activity comprising administering eplerenone, or derivatives thereof.
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申请公布号 |
US2004048840(A1) |
申请公布日期 |
2004.03.11 |
申请号 |
US20030645564 |
申请日期 |
2003.08.22 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
RUDOLPH AMY E.;MCMAHON ELLEN G. |
分类号 |
A61K45/00;A61K31/00;A61K31/56;A61K31/585;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P21/00;A61P25/00;A61P43/00;(IPC1-7):A61K31/585 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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