发明名称 Benzimidazolone histamine H3 antagonists
摘要 Disclosed are novel compounds of the formula wherein R<1 >is benzimidazolone derivative, M<1 >and M<2 >are optionally substituted carbon or nitrogen, R<2 >includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of formula I in combination with a H1 receptor antagonist.
申请公布号 US2004048843(A1) 申请公布日期 2004.03.11
申请号 US20030414943 申请日期 2003.04.16
申请人 SCHERING CORPORATION 发明人 TING PAULINE C.;ASLANIAN ROBERT G.;BERLIN MICHAEL Y.;BOYCE CHRISTOPHER W.;CAO JIANHUA;MANGIARACINA PIETRO;MCCORMICK KEVIN D.;MUTAHI MWANGI W.;ROSENBLUM STUART B.;SHIH NENG-YANG;SOLOMON DANIEL M.;TOM WING C.;ZENG QINGBEI
分类号 C07D487/04;A61K31/4545;A61K31/501;A61K31/506;A61K31/517;A61K31/5377;A61P1/00;A61P3/04;A61P9/00;A61P9/02;A61P11/00;A61P11/02;A61P25/00;A61P25/06;A61P25/18;A61P25/20;A61P25/28;A61P37/08;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04;(IPC1-7):A61K31/53;A61K31/52;A61K31/519 主分类号 C07D487/04
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