NOVEL QUATERNARY AMMONIUM COMPOUNDS

摘要

It is intended to provide drugs useful as preventives and remedies for hyperlipemia, etc., drugs useful as preventives and remedies for hepatopathy accompanying cholestasis (in particular, primary biliary cirrhosis, primary sclerosing cholangitis, etc.), and drugs useful as remedies and preventives for obesity, fat liver and fatty hepatitis, each containing as the active ingredient a benzothiazepine compound having a thioamide bond and a quaternary ammonium substituent as represented by the following general formula (1): (1) A...ortho B...meta C...para It is further intended to provide remedies and preventives for hepatopathy accompanying cholestasis which contain as the active ingredient a compound inhibiting an ileal bile acid transporter.